Channels are designed on silicon wafers, and liquid dimethylsiloxane is poured onto these wafers and heated to harden the dimethylsiloxane. When the dimethylsiloxane is removed, even the smallest microchannel design details are printed on the PDMS board. With this special silicone rubber plate, hydrophilic surface modification is performed using a reactive ion etching machine. Once the surface bond is broken, usually a slide is placed on the activated side of the siloxane. Once the bond is returned to its normal state, the glass is permanently bonded to the dimethylsiloxane plate, transforming the originally designed channel from the silicon plate into a waterproof channel. With this technology, components such as microchannels, micromixers, micropumps, and microvalves can be manufactured inexpensively, with even the smallest transliterated geometry at the nanoscale.